Monday, November 28, 2011

British film director Ken Russell dies at 84

FILE- British film director Ken Russell with British model Twiggy during the filming of the movie "The Boy Friend", at Elstree Studios, north of London, England, in this file photo dated Aug. 4, 1971. Ken Russell has died aged 84 it is announced Monday Nov. 28, 2011. Russel, whose daring and sometimes outrageous films often tested the patience of audiences and critics, his films included "The Music Lovers" in 1970, "Lisztomania", and the rock opera "Tommy" in 1975.(AP Photo/file) (AP Photo)

FILE- British film director Ken Russell with British model Twiggy during the filming of the movie "The Boy Friend", at Elstree Studios, north of London, England, in this file photo dated Aug. 4, 1971. Ken Russell has died aged 84 it is announced Monday Nov. 28, 2011. Russel, whose daring and sometimes outrageous films often tested the patience of audiences and critics, his films included "The Music Lovers" in 1970, "Lisztomania", and the rock opera "Tommy" in 1975.(AP Photo/file) (AP Photo)

FILE- British film director Ken Russell at a reception to launch the film "The Boy Friend", in London, England, in this file photo dated April 22, 1971. Ken Russell has died aged 84 it is announced Monday Nov. 28, 2011. Russel, whose daring and sometimes outrageous films often tested the patience of audiences and critics, his films included "The Music Lovers" in 1970, "Lisztomania", and the rock opera "Tommy" in 1975. (AP Photo/Bob Dear, file)

(AP) ? Director Ken Russell got Oliver Reed and Alan Bates to wrestle naked, turned Vanessa Redgrave into a demonic nun and cast Ringo Starr as the pope. Critics and mainstream audiences often hated his films. Actors and admirers loved him.

The iconoclastic British director, whose death at age 84 was announced Monday, made films that blended music, sex and violence in a potent brew.

Only a few of his movies were commercial successes. The best known were "Women in Love," an Academy award-winning adaptation of D.H. Lawrence's novel, and "Tommy," which turned The Who's rock opera into a psychedelic extravaganza complete with appearances from Elton John, Eric Clapton and Tina Turner.

Pete Townshend, who wrote "Tommy," described Russell as a "grand dame" who brought to his films about music the "lavish affection and the kind of grandiosity only musicians and composers can dream of."

"He believed all artistic work could be made to come alive over and over again," Townshend said.

Russell was fascinated with altered mental states and loved horror, religious turmoil and Gothic excess. Critics could be sniffy ? Pauline Kael once wrote that Russell's films "cheapen everything they touch."

But many in the film industry felt his influence was underrated.

Supermodel Twiggy, who starred in Russell's 1971 film "The Boy Friend," said directors like Steven Spielberg and George Lucas "say that as a kid they would watch Ken Russell movies. I don't think he got the attention he deserved."

Glenda Jackson, who won a best actress Academy Award for "Women in Love," said Russell was an "incredible visual genius."

"It's an absolute shame that the British film industry has ignored him," she said. "It's an absolute disgrace ... he broke down barriers for so many people."

"Women in Love," in 1969, was one of Russell's biggest hits, earning Academy Award nominations for the director and for writer Larry Kramer, as well as winning Jackson an Oscar. It included one of the decade's most famous scenes ? a nude wrestling bout between Bates and Reed.

Reed said at the time the director was "starting to go crazy."

"Before that he was a sane, likable TV director," Reed said. "Now he's an insane, likable film director."

Paul McGann, who starred in Russell's "The Rainbow," said the director "encouraged an irreverent joyousness on set and usually got it."

"I remember him sat on a camera crane in kaftan and sandals shouting to us through a megaphone: 'Even greater heights of abandon!'" McGann said. "He's how you imagined, and hoped, a movie director would be."

Born in the English port of Southampton in 1927, Russell fell in love with the movies as a child.

In one of his last interviews, he said his whole life, including his filmmaking, had been affected by the death of his cousin Marion, who stepped on a land mine when they were children.

"There was nothing I could do, that was the end of her," he said in the interview for the Sky Arts TV channel. "She was blown to pieces. It was something I couldn't get out of my mind and it remained with me forever."

Attracted by the romance of the sea, Russell attended Pangbourne Nautical College before joining the Merchant Navy at 17 as a junior crew member on a cargo ship bound for the Pacific. He became seasick, soon realized he hated naval life and was discharged after a nervous breakdown.

Desperate to avoid joining the family's shoe business, he studied ballet and tried his hand at acting before accepting he was not much good at either. He then studied photography, for which he did have a talent, and became a fashion photographer before being hired to work on BBC arts programs, including profiles of the poet John Betjeman, comedian Spike Milligan and playwright Shelagh Delaney.

"When there were no more live artists left, we turned to making somewhat longer films about dead artists such as Prokofiev," Russell once said.

These quickly evolved from conventional documentaries into something more interesting.

"At first we were only allowed to use still photographs and newsreel footage of these subjects, but eventually we sneaked in the odd hand playing the piano (in 'Prokofiev') and the odd back walking through a door," Russell said. "By the time a couple of years had gone by, those boring little factual accounts of the artists had evolved into evocative films of an hour or more which used real actors to impersonate the historical figures."

Music played a central role in many of Russell's films, including "The Music Lovers" in 1970, about the composer Tchaikovsky ? Russell sold it to the studio with the pitch "it's about a nymphomaniac who falls in love with a homosexual."

The same unorthodox approach to costume drama informed 1975's "Lisztomania," which starred Roger Daltrey of The Who as 19th-century heartthrob Franz Liszt, with Beatles drummer Starr playing the pope.

"The Boy Friend," a 1971 homage to 1930s Hollywood musicals starring Twiggy, and Russell's 1975 adaptation of "Tommy," were musicals of a different sort, both marked by the director's characteristic visual excess.

Russell's darker side was rarely far away. "Dante's Inferno," a 1967 movie about the poet Dante Gabriel Rossetti, played up the differences between Rossetti's idealized view of his wife and her reality as a drug addict.

Russell was even more provocative in his 1970 film "The Dance of the Seven Veils: A Comic Strip in Seven Episodes." It presented the composer Richard Strauss as a crypto-Nazi, and showed him conducting Rosenkavalier waltzes while SS men tortured a Jew.

"The Devils," a 1971 film starring Redgrave as a 17th-century nun in the grip of demonic possession, was heavily cut for its U.S. release and is due to be released on DVD in Britain for the first time in 2012.

Russell told The Associated Press in 1987 that he found such censorship "so tedious and boring." He called the American print of "The Devils" ''just a butchered nonsense."

Admirers luxuriated in his overripe, gothic sensibility ? on display once again in "Gothic," a 1987 film about the genesis of Mary Shelley's horror tale "Frankenstein" replete with such hallucinatory visuals as breasts with eyes and mouths spewing cockroaches.

Russell said his depiction of a drug-addled Percy Bysshe Shelley was an accurate depiction of the time.

"Everyone in England in the 19th century was on a permanent trip. He must have been stoned out of his mind for years," Russell said. "I know I am."

Russell's fascination with changing mental states also surfaced in 1980 film "Altered States," a rare Hollywood foray for him, starring William Hurt as a scientist experimenting with hallucinogens.

Later films included the comic horror thriller "The Lair of the White Worm" in 1988, which gave an atypical early role to Hugh Grant as a vampire worm-battling lord of the manor.

Russell also directed operas and made the video for Elton John's "Nikita."

Married four times, Russell is survived by his wife Elize Tribble and his children.

The director's son, Alex Verney-Elliott, said Russell died in a hospital Sunday following a series of strokes. Russell lived in the town of Lymington in southern England.

"My father died peacefully," Verney-Elliott said. "He died with a smile on his face."

His widow said Russell was working on a musical feature film of "Alice in Wonderland" when he died.

Funeral details were not immediately announced.

___

Associated Press writers Meera Selva and Robert Barr contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2011-11-28-EU-Britain-Obit-Russell/id-0e106e09b4834a8bbc8f29c52574c110

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Police: Utah man viewed child porn on Mass. flight (Providence Journal)

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Gingrich momentum continues with newspaper's endorsement (Star Tribune)

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Sunday, November 27, 2011

Curisma Offers DIY Coolhunting

Like putting a donk on it, it seems like every new website needs to have a daily deal. Take Curisma, for example. On the surface it's sort of an Oink-like website dedicated to the curation of cool products. Underneath, like a the cowbell in Don't Fear The Reaper, is a daily deals site. Luckily, the curation of Curisma is far more interesting than the daily deal, which just might save this start-up.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/klAI0eknCek/

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Rhoda P. Curtis: Routine and Ritual: Two Pillars as We Age

There are two support patterns that help to structure our lives--routine and ritual, and they are not the same. Routine means habits that give form to our daily lives--brushing our teeth, changing our underwear, eating at specific times, making appointments. Routine requires discipline, and it begins very early. It sustains us as we age. We organize pills according to day and quantity. We write things down on our calendars. It helps relieve the anxiety about "What do I do next?" or "What was I supposed to do today?"

There's a wonderful joke I like to share with friends who say they are having "a senior moment." An aging couple goes to their doctor, complaining that they keep forgetting things; they want advice as to how to improve their memories. The doctor advises them, "Write everything down!" They go home, and that evening, while watching a TV program, the wife says to the husband, "I'm thirsty. Would you mind getting me a soft drink from the refrigerator?" "Sure," he says, and starts to leave. "Wait! The doctor says to write everything down!" "I'm only going to the kitchen, for heaven's sake." Half an hour later, he returns with an omelet. "Where's the toast?" she asks.

Now all I have to do is say, "Where's the toast?" and my friends relax about their so-called senior moments.

Creating a routine gives us a sense of security. We are relieved from having to decide on when and how to do small, unimportant activities like where to sit at the table--which fork or spoon to use--whether to have coffee or tea. These simple, everyday activities reassure us, and unless we decide to change, we don't have to think about that change. My friends, also in their eighties or nineties, who live alone, have a routine for their week's morning activities: An egg on Mondays, Wednesdays and Fridays; cereal on Tuesdays, Thursdays and Saturdays; waffles or pancakes on Sundays. They also have regular routine activities for the rest of their days; classes, the gym, religious meetings; book clubs, coaching at public schools, whether elementary or high school. They know that involvement in community activities or active participation with other people makes them feel valued--not detached from the world.

Ritual is different. It is connected to a rite celebrating a particular occasion or initiation. Yes, it requires repetition and practice of a sort, and yes, it does require discipline, but the purpose is different. It is ceremonial; it is dramatic, and it is not commonplace or something that is practiced every day. Muslims who pray several times a day, Buddhists who meditate several times a day, Jews who recite prayers in the morning, facing East, Christians who pray before each meal and before going to bed, may create these ritualistic behaviors as part of a routine, but they are not. Rituals demand thought, often an inner meditation on an abstract concept, whereas a routine is performed without conscious thinking.

Rituals demand attention to process as well as to affect. When we participate in a ritual, like going to a place of worship on a particular day, we make a commitment to join other people in a rite of passage. Weddings, funerals, baby-naming, birthday celebrations, graduations, conferring of honorary degrees all demand certain particular behaviors and even socially acceptable clothing. A baby-naming is a ritual connected to a rite of initiation into a tribe, and is performed differently according to tribal custom. The same, of course, is true of courtship, marriage and funeral customs.

Ritual connects us to our community and to society in general. Routine reinforces our sense of control over our every-day lives. We need both routine and ritual. Without routine, we are beset with decision-making over the smallest, most mundane aspects of daily life; without ritual, we deprive ourselves of connecting with other members of our tribe or social group.

When we are young, our parents create routines for us that make their lives (and ours) easier. They insist we do our homework at a specific time every day; that we have breakfast and dinner at a specific time; that we do chores around the house or garden according to a specific schedule. As teens, we often resist their scheduling, and try to set up our own schedules, establishing our own routines. The process is important, even if it is not often successful.

We need both routine and ritual. We crave the patterns of socialization--they remind us of our connection to others. Routine helps us to organize our time, creating schedules that fit our needs. Routine helps to give form to our daily lives. Ritual expands our horizons to aspects of life beyond daily requirements. We need both pillars to sustain us, especially as we age.

Rhoda P. Curtis is the author of "Rhoda: Her First Ninety Years," a candid memoir of a first-generation American woman who was willing to change the direction of her life every 12 years, and "After Ninety: What." To buy Rhoda's books and to read her blog, visit her on Red Room.

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Source: http://www.huffingtonpost.com/rhoda-p-curtis/routine-and-ritual-two-pi_b_1113845.html

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Mike Spann: CIA Officers Seek Donations To Mark 10th Anniversary of First U.S. Combat Death In Afghan War

WASHINGTON -- CIA officers are asking people to mark the 10th anniversary of the death of the first American killed in the Afghan war by donating to help the children of their fellow fallen.

Since the death in 2001 of CIA officer Mike Spann, a total of 23 stars have been added to the wall at the CIA's Langley, Va., headquarters that honors CIA operatives lost. Many were killed in the wars in Afghanistan and Iraq.

The clandestine world rarely breaks its silence, especially when it comes to family, but the CIA Officers Memorial Foundation notes about 56 children of those killed in the line of duty will need educational support over the next 17 years.

Spann was part of a small group of CIA paramilitary officers who went into Afghanistan just 16 days after the al-Qaida attacks of Sept. 11, 2001. Less than two months later, the CIA along with U.S. Special Forces Green Berets and a massive aerial bombing campaign helped Afghan militias drive out the ruling Taliban.

Spann was killed when hundreds of Taliban and al-Qaida prisoners, guarded by just a handful of Afghans, tried to escape from a fortress jail in Mazar-e-Sharif in northern Afghanistan.

Spann is survived by his wife, Shannon, a retired CIA officer, and three children.

___

Online:

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Source: http://www.huffingtonpost.com/2011/11/25/cia-donations-mike-spann-death_n_1112603.html

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Saturday, November 26, 2011

Top Marine spends Thanksgiving in Afghanistan (AP)

COMBAT OUTPOST HANSON, Afghanistan ? A turkey trot it was not.

The U.S. Marines' top general, James Amos, sprinted up and down the Helmand River Valley in southern Afghanistan on Thursday, visiting frontline Marines at nine remote outposts to share Thanksgiving and applaud their gains against the Taliban in a region where al-Qaida hatched the 9/11 plot a decade ago.

Traveling mostly in an MV-22 Osprey, the hybrid that flies like an airplane and takes off and lands like a helicopter, Amos began shortly after daylight and finished 14 hours later ? and, improbably, managed to confront just one turkey dinner.

At one point the 65-year-old Amos referred to his unusual daytrip as the "Bataan death march," a reference to the gruesome forced march of American POWs in the Philippines during World War II.

Amos shook hands with hundreds of Marines, all veterans of tough fighting in Helmand Province, which has been a focal point of the U.S.-led strategy to counter the Taliban and other insurgent groups. The Marines have vastly improved security in Helmand over the past year, but with President Barack Obama having ordered 33,000 U.S. troops to withdraw from Afghanistan by next September, the prospects for sustaining those gains are uncertain, and the subject of debate at home.

At each stop Amos struck similar themes in pep talks to his Marines: they are coming close to winning, and when the Marine Corps leaves Afghanistan it will shift its focus to the Pacific, where he said "a whole lot of opportunities" will await a Corps no longer bogged down by land wars in the greater Middle East. He also said Thanksgiving is a time for Marines to reflect on "the unique fraternal bond" among men and women at war.

Marine Sgt. Maj. Michael Barrett, the top enlisted Marine, who accompanied Amos, said that for most troops Thanksgiving was just another day at war ? until they finished their work.

"Then they'll have a meal of a lifetime," he said.

The feast was finally set for Amos when he arrived after dark at Camp Dwyer, the southern-most stop on his trip. He helped heap plates with roast turkey, baked ham and prime rib ? with all the traditional fixings ? and then sat amongst the troops to finish it off.

Amos said "Happy Thanksgiving" at each Marine outpost, but the troops did not seem in a festive mood ? at least in the presence of their commandant. The business of war does not take a holiday. When he asked the Marines what was on their minds, they asked about the future of the Corps, the latest of Washington's stalled budget debate, the possibility of seeing some of their retirement benefits go away, and internal Marine issues.

Some conveyed a sense of confidence that Afghanistan would soon be behind them.

At Combat Outpost Hanson, one member of the 3rd battalion, 6th Marine Regiment asked, "Who do you want us to fight next, sir?" Amos said he did not know, but he reassured the Marine that there would be no shortage of security crises in the years ahead.

At Combat Outpost Alcatraz, in Sangin district where fierce fights against the Taliban have waned only recently, the top overall commander of the war, Marine Gen. John Allen, joined Amos for a pep talk to several dozen Marines.

Allen said Marines will "go home under the victory pennant," but he stressed that the struggle to degrade Taliban influence and build up Afghan security forces ? in Helmand and throughout Afghanistan ? is far from over.

"As big as this is, and as hard as it has been, we are going to be successful here," Allen said. "We're going to win this. We're going to liberate these people, we're going to set this country up to be a free country in one of the toughest regions in the world."

There are now about 97,000 U.S. troops in Afghanistan. All are scheduled to leave by the end of 2014.

Amos clearly relished the chance to see so many combat Marines, but his trip was no joy ride. His itinerary was a closely-held secret, and the aircraft on which he flew was heavily armed.

As a CH-53 helicopter lifted off from a barren field across a dirt highway in the northern Helmand village of Puzeh, with Amos and part of his entourage aboard, a bearded special operations Marine quipped, "Cross your fingers." And then, as the chopper rose above a billowing wall of powdery dust, the Marine added, only half jokingly, "Whew! Getting the commandant shot down at your (outpost) would not be a good thing."

___

Robert Burns can be reached on Twitter at http://www.twitter.com/robertburnsAP

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111125/ap_on_re_as/as_thanksgiving_marines_at_war

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Arianna Speaks At The 'Opportunity Nation' Summit

On November 4th, Arianna participated in the "Opportunity Nation" Summit in New York City. Fareed Zakaria, New York City Mayor Michael Bloomberg and others also participated in the Summit. The event is described on the "Opportunity Nation" website as follows:

The summit will feature a small number of influential speakers who will speak both about their own experiences with opportunity - events and moments that shaped their lives - as well as highlight examples of how their work creates opportunity for others.

The topic of discussion for Arianna's appearance was the "American Dream."

Arianna appeared on-stage along with The Washington Post's Michael Gerson, who was also a special assistant to President George W. Bush.

"My view of what is happening is that almost as though we're looking at a split-screen reality. And depending on which side of the screen you are looking at, you can be deeply pessimistic or deeply optimistic," said Arianna.

She mentioned that "one side of the screen" includes grim unemployment and foreclosure statistics. In addition, Arianna stated, the United States ranks "10th in upward mobility," which she explained puts us "behind France." She continued, that's "as if France would be behind us in croissants and afternoon sex, because, you know, upward mobility is sort of at the heart of the American Dream."

Arianna also mentioned "the other side of the screen." On that flip side, according to Arianna, "we do have an explosion of empathy and compassion and creativity at the community level very often." She relayed a conversation that she had with Pastor Rick Warren in which the two discussed how "churches, synagogues and local institutions are coming together to make a difference."

Arianna also explained that the founding fathers of capitalism "all were very concerned about a moral foundation to capitalism," but that today that "moral foundation" has fallen by the wayside.

"It's almost as though we went from a country that makes things, to a country that makes things up," explained Arianna. She cited "credit default swaps, derivatives, you know ways to make money that do not add value" as the manifestation of this syndrome.

She concluded, "The more we can strengthen the part of us that ultimately brings us together rather than tears us apart, the more likely it is that we'll be able to get out of this crisis and not just survive, but thrive at a higher level."

Click here to view Arianna's appearance (via C-SPAN). Her portion of the video begins at 01:07:00.

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Source: http://www.huffingtonpost.com/2011/11/24/arianna-opportunity-nation-summit_n_1112242.html

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Robin Gibb says "on road to recovery" (Reuters)

LOS ANGELES (Reuters) ? Singer Robin Gibb of the Bee Gees on Wednesday said he is on the road to recovery after being "very unwell" in recent days, and he thanked fans for their support in a message posted on his website.

"I wish to thank my family, friends and fans and the many thousands of people who do not know me but have enjoyed Bee Gees music and have wished me well," wrote Gibbs.

"I have been very unwell and am now on the road to recovery, and your prayers and wishes are a great tonic to me," the singer added.

The message comes after British media outlets in recent days reported that Gibb, 61, was battling liver cancer. Several of his representatives, however, either declined to confirm those reports to Reuters or were unavailable to comment.

Last month, he was hospitalized for abdominal pain and was treated for colon inflammation. After being released by doctors, he issued a statement saying he planned to return to work, according to media reports at the time.

Gibb is one of the surviving members of the Bee Gees, a band he formed with his twin brother Maurice and younger brother Barry in the 1960s, and achieved international success with hits such as "How Can You Mend A Broken Heart," "Stayin' Alive" and "Night Fever."

(Reporting by Piya Sinha-Roy; Editing by Bob Tourtellotte)

Source: http://us.rd.yahoo.com/dailynews/rss/celebrity/*http%3A//news.yahoo.com/s/nm/20111124/people_nm/us_robingibb

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iomega SuperHero Backup & Charger for iPhone Review

When I recently updated my iPad 2 to iOS 5, something went wrong and I lost the backup of my iPad 2 – which meant I had lost all my pictures and notes from the iPad 2. ?Of course, iOS 5 lets you backup everything to the cloud now, but I’m still a bit upset [...]

Source: http://the-gadgeteer.com/2011/11/25/iomega-superhero-backup-charger-for-iphone-review/

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Friday, November 25, 2011

UIC study identifies a key molecular switch for telomere extension by telomerase

UIC study identifies a key molecular switch for telomere extension by telomerase [ Back to EurekAlert! ] Public release date: 23-Nov-2011
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Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago

Researchers at the University of Illinois at Chicago College of Medicine describe for the first time a key target of DNA damage checkpoint enzymes that must be chemically modified to enable stable maintenance of chromosome ends by telomerase, an enzyme thought to play a key role in cancer and aging.

Their findings are reported online in Nature Structural and Molecular Biology.

Telomeres are the natural ends of chromosomes, consisting of specialized DNA-and-protein structures that protect chromosome ends and ensure faithful duplication of chromosomes in actively dividing cells. An essential player in telomere maintenance is an enzyme complex called telomerase. Without telomerase, telomeres become progressively shorter each time the cell divides.

If telomeres become too short, chromosome ends will be recognized as broken, prompting DNA-damage checkpoint proteins to halt cell division and DNA repair proteins to fuse or rearrange the chromosome ends. Telomere dysfunction has been linked to tumor formation and premature aging in humans.

The UIC study, led by Toru Nakamura, associate professor of biochemistry and molecular genetics, focused on understanding how two DNA-damage checkpoint enzymes called ATM and ATR contribute to the regulation of telomerase.

"Our current study found that ATM and ATR help to switch on the telomere complex by chemically modifying a specific target protein bound to telomeric DNA, which then attracts telomerase, much like honey bees are attracted if flowers open and show bright colors," Nakamura said.

The study was done in fission yeast cells, a model organism that utilizes very similar protein complexes as human cells do to maintain telomeres. Previous discoveries in fission yeast have provided key information that helped identify several key factors required in maintenance of human telomeres.

Nakamura thinks that a similar ATM/ATR-dependent molecular switch may exist in human cells to regulate telomere maintenance. However, certain details of the protective complex regulation may be different, he noted.

Because deregulation of telomere maintenance mechanisms is a key event in tumor formation, understanding how cellular components collaborate to generate functional telomeres may be important to finding ways to prevent cancer, Nakamura said.

###

The study was supported by grants from the National Institutes of Health and the Federal Work Study Program. Bettina Moser, UIC research assistant professor in biochemistry and molecular genetics, was first author of the study. Graduate student Ya-Ting Chang and undergraduate student Jorgena Kosti also contributed to the study.

For more information about UIC, visit www.uic.edu



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


UIC study identifies a key molecular switch for telomere extension by telomerase [ Back to EurekAlert! ] Public release date: 23-Nov-2011
[ | E-mail | Share Share ]

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago

Researchers at the University of Illinois at Chicago College of Medicine describe for the first time a key target of DNA damage checkpoint enzymes that must be chemically modified to enable stable maintenance of chromosome ends by telomerase, an enzyme thought to play a key role in cancer and aging.

Their findings are reported online in Nature Structural and Molecular Biology.

Telomeres are the natural ends of chromosomes, consisting of specialized DNA-and-protein structures that protect chromosome ends and ensure faithful duplication of chromosomes in actively dividing cells. An essential player in telomere maintenance is an enzyme complex called telomerase. Without telomerase, telomeres become progressively shorter each time the cell divides.

If telomeres become too short, chromosome ends will be recognized as broken, prompting DNA-damage checkpoint proteins to halt cell division and DNA repair proteins to fuse or rearrange the chromosome ends. Telomere dysfunction has been linked to tumor formation and premature aging in humans.

The UIC study, led by Toru Nakamura, associate professor of biochemistry and molecular genetics, focused on understanding how two DNA-damage checkpoint enzymes called ATM and ATR contribute to the regulation of telomerase.

"Our current study found that ATM and ATR help to switch on the telomere complex by chemically modifying a specific target protein bound to telomeric DNA, which then attracts telomerase, much like honey bees are attracted if flowers open and show bright colors," Nakamura said.

The study was done in fission yeast cells, a model organism that utilizes very similar protein complexes as human cells do to maintain telomeres. Previous discoveries in fission yeast have provided key information that helped identify several key factors required in maintenance of human telomeres.

Nakamura thinks that a similar ATM/ATR-dependent molecular switch may exist in human cells to regulate telomere maintenance. However, certain details of the protective complex regulation may be different, he noted.

Because deregulation of telomere maintenance mechanisms is a key event in tumor formation, understanding how cellular components collaborate to generate functional telomeres may be important to finding ways to prevent cancer, Nakamura said.

###

The study was supported by grants from the National Institutes of Health and the Federal Work Study Program. Bettina Moser, UIC research assistant professor in biochemistry and molecular genetics, was first author of the study. Graduate student Ya-Ting Chang and undergraduate student Jorgena Kosti also contributed to the study.

For more information about UIC, visit www.uic.edu



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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Source: http://www.eurekalert.org/pub_releases/2011-11/uoia-usi112311.php

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Thursday, November 24, 2011

US troops celebrate last Thanksgiving in Iraq (AP)

COS ECHO, Iraq ? American troops marked their last Thanksgiving in Iraq Thursday with turkey, stuffing and a rocket fire alarm.

Fewer than 20,000 American troops remain in Iraq at eight bases across the country. All of the forces must be out of Iraq by the end of this year, and American soldiers have been busily packing up their equipment and heading south.

Many of the bases no longer have civilian contractors making meals for them, so the troops have been eating prepackaged meals.

At COS Echo in southern Iraq, the soldiers celebrated the occasion with a special meal including turkey, stuffing, and pumpkin pie. Bottles of nonalcoholic sparkling cider were brought in especially for the occasion. The incoming rocket alarm was nothing special for the holiday ? they're heard all the time.

Lt. Col. Robert Michael Rodriguez from Santa Fe, N.M. said they worked especially hard to make the food as good as possible for what could be the last Thanksgiving in a war zone for many of the assembled troops.

"All of the commanders and the first sergeants and myself have been serving the soldiers all day. All the fixings, turkey, ham, lobster, shrimp. Trying to make it as close to home as possible," he said.

Thanksgivings in the U.S. are more about food and footballs games, not warfare. The afternoon meal at Echo was marked by the distinctive, loud whirring sound signaling incoming fire at the base, and all the soldiers hit the floor. It was unclear if anything hit the base located near Diwaniyah, 80 miles (130 kilometers) south of Baghdad.

U.S. military officials have blamed Shiite militias backed by Iran for much of the violence in southern Iraq directed at departing American forces.

Attacks have let up in recent months compared to the frequent rocket barrages fired at U.S. troops over the spring and summer. American commanders say they are prepared for further violence against their forces as U.S. troops leave the country.

"They are probably going to shoot at us the last day that we are here," Gen. Lloyd Austin, the top American general in Iraq told soldiers during a stop at Camp Victory in Baghdad Thursday.

Austin spent the day touring many of the remaining bases around the country including Echo. He said he has spent six of his last nine Thanksgivings deployed in places such as Iraq, Afghanistan and Qatar.

As he prepares to wrap up America's military presence in Iraq, Austin said he is heartened by the improvements that he's seen since he first came into the country with the initial invasion force in 2003.

"We've seen things ebb and flow, and we've seen a very persistent effort to help the Iraqis move forward. And you can see that progress as you go from place to place. It's going to take time, and we're hopeful that the right decisions will continue to be made," Austin told The Associated Press in an interview Thursday.

The dangers Iraq faces after American troops leave was on display Thursday. In the southern city of Basra, 19 people were killed and dozens more injured when three bombs went off in an open-air market.

Violence has dropped considerably since the dark days of the insurgency, but the threat from Shiite militias with loyalties to Iran, as well as Sunni militants such as al-Qaida, remains potent.

Many of the troops marking the U.S. military's eighth and final Thanksgiving in Iraq have experienced multiple deployments, as part of an all-volunteer military that has been waging wars on two fronts for nearly a decade.

"I came here in the invasion. It was a little rough at the beginning. We lost a lot of friends, lost a lot of battle buddies," said Sgt. 1st Class Fred Enrique Fox from Ft. Hood, Texas. "It got better tour after tour, but the first one was the hardest one."

The 32-year-old said he has done four tours in Iraq and has spent time in Fallujah, once the center of the insurgency in Anbar province, and the once-volatile city of Iskandariyah, 30 miles (50 kilometers) south of Baghdad.

During this tour his platoon is helping secure the main road through Iraq, by which almost all American equipment and many U.S. soldiers will travel out of the country into Kuwait by the end of this year.

He said he is looking forward to being home to see the birth of his baby daughter in February, but now he's concentrating on getting his troops home safely.

"That is my biggest focus, making sure my 24 guys get home alive," he said before going back to help serve food to the troops.

Source: http://us.rd.yahoo.com/dailynews/rss/iraq/*http%3A//news.yahoo.com/s/ap/20111124/ap_on_re_mi_ea/ml_iraq_last_thanksgiving

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France calls for humanitarian zone in Syria (Reuters)

AMMAN/PARIS (Reuters) ? France has called for a "secured zone to protect civilians" in Syria, the first time a major Western power has suggested international intervention on the ground in the eight-month uprising against President Bashar al-Assad.

Foreign Minister Alain Juppe also described Syria's exiled opposition National Council as "the legitimate partner with which we want to work," the biggest international endorsement yet for the nascent opposition body.

A spokesman for European Union foreign policy chief Catherine Ashton said the EU was ready to engage with the Syrian National Council and other opposition groups, but stressed the need for them to maintain a peaceful, non-sectarian approach.

Asked at a news conference on Wednesday after meeting the SNC president if a humanitarian corridor was an option for Syria, Juppe ruled out military intervention to create a "buffer zone" in northern Syria but suggested a "secured zone" may be feasible to protect civilians and ferry in humanitarian aid.

"If it is possible to have a humanitarian dimension for a secured zone to protect civilians, that then is a question which has to be studied by the European Union on the one side and the Arab League on the other side," Juppe said.

Further details of the proposal were not immediately available. Until now, Western countries have imposed economic sanctions on Syria but have shown no appetite for intervention on the ground in the country, which sits on the fault lines of the ethnic and sectarian conflicts across the Middle East.

"The French have tried to position themselves in a position of leadership, first with Libya and now here," said Hayat Alvi, a lecturer in National Security studies, at the U.S. Naval War College. "Military intervention in Syria is a very different prospect of that in Libya, but we could well see an increase in covert action."

The Arab League has suspended Syria's membership over the conflict, one of the most important signs of Assad's isolation, but has shown little appetite for international intervention.

Britain said it welcomed the opportunity to discuss the French proposal and repeated its call for Syria to end human rights violations.

Ashton's spokesman said the EU foreign policy chief had met this week with leaders of the Syrian National Council. "The EU stands ready to engage with the Syrian National Council and other representative members of the opposition who adhere to non-violence and democratic values," he said.

Addressing the need for a humanitarian response, he said: "Protection of civilians in Syria is an increasingly urgent and important aspect of responding to the events in the country."

DARKNESS OF THE MIDDLE AGES

Syria's bloodshed could pitch the Muslim world into "the darkness of the Middle Ages," Turkish President Abdullah Gul said on Wednesday.

A day earlier, Turkish Prime Minister Tayyip Erdogan criticised the "cowardice" of Assad, once a close ally, for turning guns on his own people. Erdogan spoke of the fate of defeated dictators from Adolf Hitler, Benito Mussolini to Muammar Gaddafi, and bluntly told Assad to quit.

In Brussels, an EU diplomat said European Union governments were considering a new range of sanctions against Syria that would bar investment in Syrian banks, trading its government bonds and selling insurance to state bodies.

Gul told a think-tank in London: "We exerted enormous efforts in public and behind closed doors in order to convince the Syrian leadership to lead the democratic transition."

"Violence breeds violence. Now, unfortunately, Syria has come to a point of no return," he said. "Defining this democratic struggle along sectarian, religious and ethnic lines would drag the whole region into turmoil and bloodshed."

The violence in Syria shows no sign of let-up.

Syrian forces killed two villagers on Wednesday in an agricultural area that has served as a supply line for defectors, activists and residents said.

An armored column entered the town of Hayaleen and surrounding villages on the al-Ghab Plain. Troops fired machineguns from tanks and trucks and set fire to several houses after arresting around 100 people, they said.

The region, northwest of the city of Hama, 240 km (150 miles) north of Damascus, has been a transit route for defectors operating in the province of Idlib near Turkey, activists said.

Two youths were also killed in the central city of Homs, 140-kms (88 miles) north of Damascus, which has become a center of resistance against Assad. Activists said evening demonstrations were held in several neighborhoods of Homs.

A YouTube video showed a rally being led by a local soccer player. Protesters waved green and white Syrian flags from the era before Assad's Baath Party took power in a 1963 coup and a woman sang a lament to those who had been killed, while the crowd chanted after her.

In the south, two villagers were killed near the city of Deraa on the border with Jordan, where more tanks and armoured vehicles deployed in the last month after a slew of defections and attacks on loyalist forces, activists said.

It was not possible to confirm the events independently. The authorities, who blame the unrest on "armed terrorist groups," have barred most independent media from Syria.

Thousands of soldiers have deserted the regular army since it started cracking down on the eight-month protest movement. Some have formed rebel armed units loosely linked to an umbrella "Free Syrian Army" led by officers in Turkey.

SYRIA ARMY REINFORCES NEAR BORDER

Syrian defectors say they are hopeful that Turkish troops will create a safe haven within Syria. Defectors say they could use such a zone as a staging ground to mount a rebellion.

Turkey is reluctant to take military action across the border but Turkish officials say they could set up a sanctuary on Syrian territory if huge numbers of refugees head for the frontier or if massacres take place in Syrian cities.

Ground forces commander Hayri Kivrikoglu inspected troops near the border on Tuesday, Turkish state television reported.

Syrian deserters and civilians in refugee camps and villages in Turkey close to the frontier say the Syrian army has reinforced its positions in border areas.

"There are tanks in the valleys, hidden among the trees, and they've dug trenches," Syrian refugee Hamid Fayzo told Reuters in the Turkish village of Guvecci, overlooking the border.

The United Nations says 3,500 people have been killed in the uprising, triggered by Arab revolts which have toppled leaders in Tunisia, Egypt and Libya.

Assad, 46, seems prepared to fight it out, playing on fears of a sectarian war if Syria's complex ethno-sectarian mosaic shatters.

But many experts say Assad, who can depend mainly on the loyalty of two elite Alawite units, cannot maintain current military operations without cracks emerging in the armed forces.

(Additional reporting by Suleiman al-Khalidi in Hatay, Turkey, Jonathon Burch in Ankara, Adrian Croft in London and Justyna Pawlak in Brussels; Writing by Peter Graff; Editing by Myra MacDonald)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111124/wl_nm/us_syria

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Video: Perry calls on Panetta to protest defense cuts and resign (cbsnews)

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Ohioans Share Thoughts on Fur-Free Friday PETA Events (ContributorNetwork)

The day after Thanksgiving may be well known as the biggest shopping day of the year, but the animal advocates from around the globe spend Black Friday educating rather than spending. Fur-Free Friday is a global anti-fur and animal slaughter event which began as a small movement in the late 1980s. This year more than 250 Fur-Free events will occur near shopping malls worldwide. According to PETA, which helps organize the after-Thanksgiving events, more than 50 million animals are skinned each year to provide leather for jackets, clothing, accessories and furniture coverings.

My Ohio Twitter followers shared their thoughts on Fur-Free Friday via email and instant messaging.

* "My roommates and I are going to the Fur-Free event in Cleveland this year. It is our first time helping to share information with shoppers. The events are peaceful and are an attempt to educate others about the inhumane treatment of animals just so we can fill our closets with expensive jackets." -- Neena Carter, Ohio University student, Upper Sandusky.

* "I had never heard of the events before this year. I am glad they are peaceful and don't involve throwing red paint on shoppers like some of the anit-fur protests in the early 1990s. I support their efforts but do not want to be hassled while shopping with my mother and sisters on one of the few days we all get to spend together each year." -- Melissa Stanford, nurse, Columbus..

* "I wish there were more events going on in Ohio. Especially after the tragedy at the exotic animal farm in Zanesville last month. The animals used for their fur and not just killed, they live in horrid conditions until they are skinned alive." -- Bryson Richards, graphic artist, Cincinnati.

* "I hope that the growing number of Fur-Free Friday events around the world put an end to the increase in fur sales which has occurred during the past decade. Once the movement died down in the later 1980s sales once again began creeping up. The fur industry made more than $13 billion last year, that is disgusting." -- Marcus Reed, sculpting artist, Columbus.

* "I am looking for a new leather jacket for my husband for Christmas and had better not be subjected to angry rants by PETA people. I respect their opinion and their right to protest in public spaces, but not their right to bother me while shopping." -- Donna Smathers, nurse, Lancaster.

* "PETA does such good work, I hope they get a lot of donations and make a difference in shopping habits during Fur-Free Friday. How someone could wear the skin of another creature on their back is a concept I just cannot understand. There should be a law against such cruelty." -- Rashawna Eastman, Ohio State University graduate student, Columbus.

Source: http://us.rd.yahoo.com/dailynews/rss/pets/*http%3A//news.yahoo.com/s/ac/20111123/us_ac/10513919_ohioans_share_thoughts_on_furfree_friday_peta_events

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Wednesday, November 23, 2011

Looking ahead to the runoffs (Offthekuff)

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Nuance Plays Its Cards Right With Swype (The Motley Fool)

The technology segment has never been this exciting. With the launch of upgraded tablets and Apple's (Nasdaq: AAPL - News) much-awaited iPhone -- despite the fact that users got the 4S version instead of the promised 5 -- the market has been thrown wide open for newer, better technologies.

One company that has jumped onto the bandwagon is Nuance Communications (Nasdaq: NUAN - News). Nuance, a speech recognition and digital imaging software company, last month acquired its competitor, mobile-tech firm Swype, for $102.5 million. Swype's patented technology, which makes typing on screens of mobile devices, tablets, televisions, and game consoles easier, is expected to boost Nuance's growth.

Profitable nuances
Nuance has been looking to expand aggressively in order to tap into the fast-moving smartphone and tablets market. In the past year, the company has acquired three more businesses, all of which were related to mobile device technologies. In addition to a business partnership with Apple -- iPhone 4S' Siri technology is based on its speech-recognition technology -- Nuance also supports Google's (Nasdaq: GOOG - News) Android-based mobile devices. In fact, Nuance's acquisition has sparked speculation about Google's interest in buying out the company for its speech-recognition technology. According to one analyst, Swype had 15 manufacturing partners and 50 million devices shipped in the last 18 months. The acquisition means that Nuance gets Swype's current business partnerships and much more.

Swype's acquisition is seen as a big move for Nuance, as core speech-recognition technology allows the company to provide raw materials to big players. Potential customers for its latest technology include leading mobile device manufacturers such as Research In Motion (Nasdaq: RIMM - News), Nokia (NYSE: NOK - News), or Motorola Mobility (NYSE: MMI - News).

Tracing an aggressive growth path
Nuance is leaving no stone unturned in its effort to capture market share in the mobile devices and tablet segment. In line with its expansion plans, Nuance recently partnered with distributor Mindware for the promotion of its products in the Middle East. Investors have been happy with the moves. Since the iPhone 4S was launched, Nuance's stock has risen nearly 15%, recently hitting a 52-week high.

Foolish opinion
Speech technology in mobile and tablet devices promises to be the next big thing in the technology segment. With smart acquisitions, expansion strategies, the right product mix, and big partnerships, Nuance seems to be playing its cards right. In addition, its growth is tied to the progress made in the mobile devices and tablet market, which is only expected to move northward.

Vibhuti Shah does not own any shares in the companies mentioned above. The Motley Fool owns shares of Apple and Google.

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Source: http://us.rd.yahoo.com/dailynews/rss/applecomputer/*http%3A//news.yahoo.com/s/fool/20111122/bs_fool_fool/rx165618

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Shale gas carbon footprint fears

Using shale gas could stop the UK from reducing its carbon footprint, a report has claimed.

The Co-operative report said if 20% of Lancashire's gas resources were recovered it would mean emissions totalling 2bn tonnes of carbon dioxide.

Shale gas would account for almost 15% of the UK's total allowed emissions up to 2050, the report said.

The Department of Energy and Climate Change (DECC) said shale gas's carbon footprint is similar to natural gas.

The report by the Tyndall Centre for Climate Change Research in Manchester, said that exploiting shale gas would have limited benefits in terms of replacing coal and could draw money away from investment in renewables, preventing the delivery of thousands of onshore or offshore wind turbines.

'Dash for gas'

Kevin Anderson, professor of energy and climate change at the Tyndall Centre said: "As the government's committee on climate change make clear, for the UK to meet its binding carbon budgets, electricity needs to be decarbonised by 2030 with domestic heating having moved from high-carbon gas to low-carbon electricity.

"With so little time to meet these commitments, there is no meaningful emissions allowance available for shale gas.

"Moreover, pursuing shale gas electricity risks displacing urgently required investments in genuinely low-carbon energy supply.

"Consequently the government faces a difficult choice: to lead a new and low-carbon energy revolution or stick with high carbon fossil fuels, forgo its emissions targets and relinquish its hard-won international reputation on climate change."

Paul Monaghan, head of social goals at the Co-operative, said: "This authoritative report shows that a new dash for gas is incompatible with the UK's carbon reduction targets and that a complete re-appraisal of approach is needed."

Viability 'not established'

There are also concerns over the process used to extract shale gas, known as fracking.

The study said fracking had caused earthquakes in Lancashire, with damage to one of the wells drilled into the shale seam reported as a result.

A DECC spokesman said: "The full extent of shale gas in the UK and its economic and environmental viability is yet to be established.

"At best, it is years away, and as the recent report on the Lancashire earthquakes showed, there remain issues to be addressed about hydraulic fracturing, or 'fracking'.

"However, we would expect shale gas to have a carbon footprint of the same order as natural gas from conventional onshore fields."

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/uk-england-lancashire-15839903

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Tuesday, November 22, 2011

Hormel Foods 4Q net income falls, revenue rises (AP)

Hormel Foods Corp.'s fiscal fourth-quarter profit slipped 3 percent as weak sales and higher ingredient costs hurt the maker of Spam, Dinty Moore stew and other packaged food brands.

It's a struggle playing out regularly for food makers these days: they need to raise prices to cover higher costs but risk losing cost-conscious shoppers.

Hormel said Tuesday that its total sales volume fell 7 percent, but higher prices helped nudge its revenue up and protect some of its profit. As a result, the company was able to deliver earnings per share that beat analyst expectations and it issued 2012 guidance above estimates, which sent its shares higher in late morning trading.

The company, based in Austin, Minn., said its net income fell to $117.3 million, or 43 cents per share, for the period that ended Oct. 30. That's down from $121.1 million, or 45 cents per share, in the same quarter last year. It also beat the 42 cents per share that analysts surveyed by FactSet forecast.

Its earnings per share were adjusted to account for a previously announced 2-for-1 stock split. There was also one less week in the current quarter.

Revenue edged up 2 percent to $2.1 billion but missed Wall Street's $2.13 billion estimate.

It was the second quarter in a row that the prepared foods maker dealt with slower sales volume as a result of higher prices. Like many food makers, Hormel has raised prices on its products to offset rising costs for everything from grain to packaging.

On Monday, Tyson Foods Inc. reported that its fourth-quarter net income slipped as higher grain costs offset better prices and revenue, particularly in its chicken business.

Hormel reported that its operating profit rose in four of its five operating segments: grocery products, Jennie-O turkey, specialty foods and other products. The biggest drag for Hormel came from its refrigerated foods division, where its operating profit fell 19 percent because of declining pork operating margins and increased commodity costs.

The company reported that revenue rose in all but one of its segments but sales volume fell across the board.

"Clearly, in the long run, we're looking to grow volumes of our value-added franchises," Hormel CEO Jeffrey Ettinger said. "But as long as we continue to be in this kind of pricing environment, you will continue to see larger net sales increases; then you will see volume increases. "

Hormel's full-year earnings rose 20 percent to $474.2 million, or $1.74 per share, from $395.6 million, or $1.46 per share, in the prior year. After adjusting for costs tied to the closure of a plant and other one-time items, the company earned $1.51 per share for the year versus $1.46 a year earlier.

Annual revenue increased 9 percent to $7.9 billion from $7.22 billion.

The company said it expects to continue to struggle with volatile raw material costs, higher grain costs and potentially a decline in its meat processing margins in the coming fiscal year. Hormel said it will continue to take strategic and modest price increases as needed to offset rising costs.

Hormel said it anticipates 2012 earnings in a range of $1.79 to 1.89 per share. Analysts had been expecting earnings of $1.77 per share for the year.

The company expects its grocery products, specialty foods and its international business to drive its fiscal 2012 profit growth. Ettinger cautioned that comparisons will likely be more difficult in the first half of the year, getting more favorable later in the year.

Late Monday, Hormel increased its annual dividend by 18 percent to 60 cents per share from 51 cents per share.

Hormel's shares rose 33 cents, or 1.1 percent, to $29.16 in late morning trading.

____

Michelle Chapman contributed to this report from New York. Sarah Skidmore contributed from Portland, Ore.

Source: http://us.rd.yahoo.com/dailynews/rss/earnings/*http%3A//news.yahoo.com/s/ap/20111122/ap_on_bi_ge/us_earns_hormel

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Thousands in Egypt protest military ruling council

backgroundblue line Saturday 19th November, 2011

Thousands in Egypt protest military ruling council ??



?????Saturday 19th November, 2011??Source: San Francisco Chronicle ??
Cairo -- Banners waved and angry slogans echoed as tens of thousands of Egyptians protested Friday against the ruling military council, which they blame for hijacking a revolution that once bore the hope of leading the restive Arab world toward democracy.
Dominated by Islamists and including a smattering of secularists and liberals, crowds swelle...

Breaking News
Saturday 19th November, 2011


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